Sweet-Ease is a 24% sucrose and purified water solution. Sucrose is a non-pharmacologic intervention that has been widely studied and proven to be associated with statistically and clinically significant reductions in discomfort to the infant. Preservative-free Sweet-Ease Natural may be used in all areas of the hospital, including the NICU, PICU, newborn nursery, ER or at the pediatrician’s office. Sweet-Ease administration can be supplemented by a Soothie pacifier for nonnutritive sucking to help calm and soothe distressed babies up to six months of age. Sweet-Ease Natural is packaged in two convenient sizes: 2ml vial to simplify clinician workflow by allowing the administration of sucrose directly onto the tip of an infant's tongue or buccal surface, or a 51mm translucent, spill-resistant cup (filled to 15mL) which allows for dipping the pacifier into the cup.